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Florida statute (most state constitutions have something similar) says in 381.00315 the Government in an "emergency" is granted to use any force to vaccinate -- isolate -- quarantine --  without exemption or exception!
In December 2020, the first vaccines for coronavirus disease were granted an EUA – Emergency Use Authorization – by the Food and Drug Administration (FDA) and recommended by the Advisory Committee on Immunization Practices (ACIP). 

Here is a section of 381.00315
4. b) If the individual poses a danger to the public health, the State Health Officer may subject the individual to isolation or quarantine. If there is no practical method to isolate or quarantine the individual, the State Health Officer may use any means necessary to vaccinate or treat the individual.
Any order of the State Health Officer given to effectuate this paragraph shall be immediately enforceable by a law enforcement officer under s. 381.0012.
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